Contract, Drug Metabolism and Pharmacokinetics (DMPK)

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life's moments for children and adults living with a rare disease.

At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging.

Visit our website to learn more about our company and culture!
Site: www.ptcbio.com

ESSENTIAL FUNCTIONS

Primary duties/responsibilities:

• With guidance, initiates and executes scientific research and experiments and interprets and communicates results as part of multi-disciplinary team(s).

• Performs and maintains established in vitro and in vivo metabolism/bioanalysis assays.

• With guidance, develops new, and improves upon existing DMPK assays.

• Performs hands-on in vitro and in vivo metabolism/bioanalysis assays using LC-MS/MS.

• Documents experiment details in lab books, records results in database and prepares study reports.

• Abides by all safety and regulatory guidelines.

• Performs other tasks and assignments as needed or specified by management.

• Contributes to general lab needs such as:

  • Equipment maintenance and/or troubleshooting.

  • Capital equipment purchases.

KNOWLEDGE/SKILLS/ABILITIES REQUIRED

* Minimum level of education and years of relevant work experience.

• A Master's degree in Biology, Chemistry, Biochemistry, Pharmaceutical Science, Pharmacology or other related scientific discipline and a minimum of 2 years of relevant and progressively responsible experience in a pharmaceutical, biotechnology or similar environment OR a Bachelor's degree in these same disciplines and a minimum of 4 years of the same experience.

* Special knowledge or skills needed and/or licenses or certificates required.

• Demonstrated experience in conducting in vitro and in vivo DMPK studies, such as metabolic stability in liver microsomes and hepatocytes, CYP inhibition and induction, and bioanalysis in various matrices etc.

• Demonstrated experience in operating and troubleshooting contemporary LC-MS instruments and automated liquid handlers.

• Hands-on experience with liquid handlers, LC-MS instruments and other equipment.

• Detailed knowledge of DMPK and applied techniques.

• Experience with developing and optimizing relevant DMPK assays.

• Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment that may consist of both internal and external team members.

• Proficiency with Microsoft Office.

• Good verbal and written communication skills.

• Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.

• Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects

*Special knowledge or skills and/or licenses or certificates preferred.

• Knowledge of drug metabolism and pharmacokinetics in discovery preclinical research.

* Travel requirements

• Up to 5%

• Office/Laboratory based position

Expected Hourly Range:

$45-$70/hour. The hourly salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position they are being considered for, as well as review of internal equity.

EEO Statement:

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

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